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Dr David Evans is a top neurosurgeon at a hospital in Washington. He's also a single parent after his wife died from a brain tumour he - the expert - failed to spot. Then one night when he stays late to save the life of a gang member caught in crossfire, his young daughter goes missing. He finds the nanny dead in the basement of his house. Because this is no ordinary disappearance - his daughter has been kidnapped because he is secretly about to perform surgery on the most important person in the US, the President, and there are those who don't want the man to survive. Caught between his desire to save his daughter and the terrible consequences if he fulfils the kidnappers demands, Evans is in a race against time that will mean him turning to the one person he has not spoken to in years - his dead wife's sister.