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Retroviral Insertion and Oncogene Activation

Name: Retroviral Insertion and Oncogene Activation
Brand: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
SKU: 07074229
Price: 48.29 EUR
Availability: InStock
Author: Hsing-Jien Kung
ISBN: 9783642765261

Hsing-Jien Kung

Peter K. Vogt

Language

English

Book Paperback

Libristo code: 07074229

Publishers Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, December 2011

An integrated retrovirus effectively becomes part of the cellular genome, but with the difference th... Full description

Libristo code: 07074229

118 b

48.29 € VAT included

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An integrated retrovirus effectively becomes part of the cellular genome, but with the difference that the virus to a large extent retains control over its own expression through nontranslated sequences in the long terminal repeat (L TR). Some retroviruses also code for nonstructural proteins that further regulate proviral expression. Integration changes the cell genome; it adds viral genes, and in the case of transducing retroviruses also adds cell-derived oncogenes that have been incorporated into the viral genome. Integration can also have consequences for cellular genes. The transcriptional signals in a provirus can activate expression of neighboring cellular genes; the integration even can disrupt and thus inactivate cellular genes. These effects of retroviral genomes take place in cis; they are referred to as insertional mutagenesis and are the subject of this volume. Almost 10 years have passed since W. Hayward, S. Astrin, and their colleagues found that in B cell lymphomas of chickens, induced by avian leukosis virus, transcription of the cellular proto-oncogene myc was upregulated through the integration of a complete or partial provirus in its vicinity. This landmark discovery suggested a mechanism by which retro viruses that do not carry cellular oncogenes in their genome ("nonacute retroviruses") can cause cancer. It contributed the first evidence for the carcinogen potential of oncogenes that are not part of a viral genome.