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Receptor-Ligand Interactions: A Practical Approach

Name: Receptor-Ligand Interactions: A Practical Approach
Brand: Oxford University Press
SKU: 04533994
Price: 166.59 EUR
Availability: InStock
Author: Hulme
ISBN: 9780199630912

Hulme

Language

English

Book Paperback

Libristo code: 04533994

Publishers Oxford University Press, May 1992

This book is the final part of a trilogy of volumes covering the practical aspects of ligand interac... Full description

Libristo code: 04533994

408 b

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This book is the final part of a trilogy of volumes covering the practical aspects of ligand interactions, biochemistry, and effector mechanisms of signal-transducing receptors. The book focuses on the measurement of receptor binding interactions both at equilibrium and from the kinetic point of view. In addition to descriptions of the most important techniques for the performance of ligand binding assays to both membrane-bound and solubilized receptors. A systematic effort has been made to provide insight into the strategy and tactics of receptor binding assays, and the conditions which must be satisfied if artifacts are to be avoided and interpretable data obtained. Since the behaviuor of even the simplest receptor systems can be surprisingly complex, an attempt has been made to provide some computational tools which allow complications to be predicted and handled or avoided. Ligand binding assays are very widely used, not least in drug screening and development. This volume will help the practitioner to choose an appropriate ligand, make a suitable receptor preparation, design and perform a well thought-out set of assays, and analyse the data obtained correctly.