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Optimized Response-Adaptive Clinical Trials

Name: Optimized Response-Adaptive Clinical Trials
Brand: Springer Fachmedien Wiesbaden
SKU: 09095051
Price: 53.79 EUR
Availability: InStock
Author: Thomas Ondra
ISBN: 9783658083434

Sequential Treatment Allocation Based on Markov Decision Problems

Thomas Ondra

Language

English

Book Paperback

Libristo code: 09095051

Publishers Springer Fachmedien Wiesbaden, December 2014

Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two o... Full description

Libristo code: 09095051

132 b

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Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.