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Leucocyte Trafficking

Name: Leucocyte Trafficking
Brand: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
SKU: 01562612
Price: 152.59 EUR
Availability: InStock
Author: A. Hamann
ISBN: 9783540401124

Role of Fucosyltransferases and Selectins

A. Hamann

K. Asadullah

A. Schottelius

Language

English

Book Hardback

Libristo code: 01562612

Publishers Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, October 2003

An essential component of inflammation is the migration of circulating leukocytes from blood into ti... Full description

Libristo code: 01562612

373 b

152.59 € VAT included

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An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactionsof selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.