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Inflammasomes

Name: Inflammasomes
Brand: Springer Basel
SKU: 01438852
Price: 160.89 EUR
Availability: InStock
Author: Isabelle Couillin
ISBN: 9783034801478

Isabelle Couillin

Virginie Pétrilli

Fabio Martinon

Language

English

Book Hardback

Libristo code: 01438852

Publishers Springer Basel, July 2011

The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspa... Full description

Libristo code: 01438852

394 b

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The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.