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Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here Gerald Litwack, award-wining researcher and longtime teacher, discusses biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussion of hypothalamic releasing hormones; DNA editing with CRISPR; new functions of cellular prions; plant-based diet and nutrition; structured water; glycation of proteins; epigenetics and epigenomics; biogenetics and "junk" DNA; bacterial enzymes; and thyrostimulin. Grounded in problem-driven learning, Human Biochemistry, Second Edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, empowering active clinicians, students, and researchers. Past edition winner of the 2018 Most Promising New Textbook (College) Award (Texty) from the Textbook and Academic Authors Association and the PROSE Award of the Association of American PublishersFully updated to incorporate current research in human and medical biochemistryIncludes clinical case studies, applications, chapter summaries, and review-based questionsAdopts a practice-based approach, reflecting the needs of both research and clinically oriented readers