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Genome Integrity

Name: Genome Integrity
Brand: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
SKU: 01652390
Price: 304.89 EUR
Availability: InStock
Author: Dirk-Henner Lankenau
ISBN: 9783642072260

Facets and Perspectives

Dirk-Henner Lankenau

Language

English

Book Paperback

Libristo code: 01652390

Publishers Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, November 2010

This is the first book to give a full overview on genome integrity in different species. From microo... Full description

Libristo code: 01652390

746 b

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This is the first book to give a full overview on genome integrity in different species. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. Written by an international panel of experts, the book addresses the connection between genome integrity and human disease.Cells and viruses maintain a genome capable of multiplication, variation and heredity. A genome consists of chromosomes, each being built up of two complementary strands of nucleic acid known as DNA. Its chemical integrity, however, is under constant assault from metabolic mutagens, such as hydroxy-radicals, endonucleases, radiation, replication errors, and environmental mutagens. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. The volume begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. Examples of human diseases are included and the cellular responses to radiation and genotoxic stress affecting whole genomes are reviewed.