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A ''generalised seizure'' corresponds to an ictal manifestation whose initial semeiology indicates or is consistent with more than minimal involvement of both cerebral hemispheres. A ''network'' is a functionally and automatically connected set of cortical and subcortical brain regions in which activity in any one part affects activity in all others. A ''system'' is a group of independent but interrelated elements (networks) comprising a unified whole. A considerable amount of evidence supports the existence of cortical and subcortical networks in the genesis, expression and control of generalised seizures. Animal and human data suggested that the so-called generalised seizures involve selective networks while sparing others. A greater understanding of those systems and networks is thoroughly debated in this book.
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