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Fluorouracil

Name: Fluorouracil
Brand: Nova Science Publishers Inc
SKU: 06430122
Price: 185.89 EUR
Availability: InStock
Author: Alberto C Dario Longinho
ISBN: 9781620819708

Synthesis, Health Effects & Role in Chemotherapy

Alberto C Dario Longinho

Sebastiao E Britto Dobreiro

Language

English

Book Hardback

Libristo code: 06430122

Publishers Nova Science Publishers Inc, October 2012

The fluoropyrimidine 5-fluorouracil (5-FU), an antimetabolite drug, works by being incorporated in t... Full description

Libristo code: 06430122

455 b

185.89 € VAT included

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The fluoropyrimidine 5-fluorouracil (5-FU), an antimetabolite drug, works by being incorporated in the RNA and DNA and by the inhibition of the nucleotide synthetic enzyme thymidylate synthase. It is widely used in the treatment of a range of cancers, including gastrointestinal, head and neck, and breast cancers. In this book, the authors present current research in the study of the synthesis, health effects and role in chemotherapy of fluorouracil. Topics discussed include the antiproliferative activities, cell-cycle regulation, apoptosis and cellular differentiation of acyclic 5-fluorouracil O, N-Acetals; 5-fluorouracil and its immunotoxicity and side effects; 5-fluorouracil application in the management of bleb failure; and cisplatin and 5-fluorouracil for the treatment of ovarian adenocarcinoma.