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Extrasynaptic GABAA Receptors

Name: Extrasynaptic GABAA Receptors
Brand: Springer-Verlag New York Inc.
SKU: 02745862
Price: 107.29 EUR
Availability: InStock
Author: Adam C. Errington
ISBN: 9781493914258

Adam C. Errington

Giuseppe Di Giovanni

Vincenzo Crunelli

Language

English

Book Hardback

Libristo code: 02745862

Publishers Springer-Verlag New York Inc., September 2014

GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors.... Full description

Libristo code: 02745862

263 b

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GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed tonic inhibition, has been described. Whereas synaptic GABAA receptors underlie classical phasic GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.