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Cold Thermal Processing in the Spinal Cord

Name: Cold Thermal Processing in the Spinal Cord
Brand: VDM Verlag Dr. Müller
SKU: 06819328
Price: 71.69 EUR
Availability: InStock
Author: Paul Wrigley
ISBN: 9783639103434

In Search of Therapeutic Targets for Cold Hyperesthesia

Paul Wrigley

Language

English

Book Paperback

Libristo code: 06819328

Publishers VDM Verlag Dr. Müller, November 2009

Two recently identified transient receptor potential (TRP) channels, TRPM8 and TRPA1, have been prop... Full description

Libristo code: 06819328

175 b

71.69 € VAT included

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Two recently identified transient receptor potential (TRP) channels, TRPM8 and TRPA1, have been proposed to play an important role in mammalian cool and cold peripheral sensory transduction. When expressed in cell-lines the cloned TRPM8 and TRPA1 receptors have distinct pharmacological and temperature response characteristics. Although these receptors are also transported to the central terminals of primary afferents, little is known about their centrally mediated actions. In this thesis an in vitro electrophysiological approach is used to investigate the dorsal horn processing of cool afferent modalities and the role of TRP ion channels. The results of this thesis provide further information on thermal processing, indicate direction for further research and suggest possible therapeutic targets for the management of abnormal cold sensory processing.