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Cell Cycle Control and Dysregulation Protocols

Name: Cell Cycle Control and Dysregulation Protocols
Brand: Humana Press Inc.
SKU: 01400916
Price: 101.79 EUR
Availability: InStock
Author: Antonio Giordano
ISBN: 9780896039490

Antonio Giordano

Gaetano Romano

Language

English

Book Hardback

Libristo code: 01400916

Publishers Humana Press Inc., July 2004

The dysregulation of the normal cell cycle underlies an enormous number of pathological conditions,... Full description

Libristo code: 01400916

249 b

101.79 € VAT included

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The dysregulation of the normal cell cycle underlies an enormous number of pathological conditions, including the neurodegenerative disorders, all cancers, and diabetes. In Cell Cycle Control and Dysregulation Protocols: Cyclins, Cyclin-Dependent Kinases, and Other Factors, expert laboratorians detail emerging methodologies for studying the cell cycle, its kinases, and kinase inhibitors. The authors focus on issues of gene expression in vivo and in vitro, the analysis of cyclin-dependent kinase inhibitors, protein degradation mediated by the proteosome, the analysis of the transformed cell phenotype, and innovative techniques to detect apoptosis. Many of the protocols are new, such as electron microsocopy to detect apoptosis and proteosome-mediated degradation, whereas others study the interactions between protein-protein, protein-DNA, and protein-RNA. The protocols follow the successful Methods in Molecular Biology series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.§State-of-the-art and highly practical, Cell Cycle Control and Dysregulation Protocols: Cyclins, Cyclin-Dependent Kinases, and Other Factors offers pathbreaking researchers powerful tools for probing the cell cycle regulation across a wide variety of pathologies.