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ATORVASTATIN SELF-EMULSIFIED TABLETS FORMULATION AND EVALUATION

Language EnglishEnglish
Book Paperback
Book ATORVASTATIN SELF-EMULSIFIED TABLETS FORMULATION AND EVALUATION Prafulla Kumar Sahu
Libristo code: 42835871
Publishers LAP LAMBERT Academic Publishing, December 2022
Due to poor drug solubility and absorption, many drug candidates fall short of expectations. Self-em... Full description
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Due to poor drug solubility and absorption, many drug candidates fall short of expectations. Self-emulsifying drug delivery methods increase the solubility and bioavailability of poorly soluble medications. When SEDDS are added to an aqueous phase and gently mixed, fine oil-in-water emulsions form. SEDDS come in soft or hard gelatin capsules for oral administration and form fine, stable oil-in-water emulsions. SEDDS are primarily manufactured as liquid formulations, which have poor stability and mobility, low drug loading, a limited number of dosage form options, irreversible drug/excipient precipitation, and a high proportion (30-60%) of surfactants that might irritate the gastrointestinal system. Solid-SEDDS has been studied to avoid the problems of liquid SEDDS. The adsorption of liquid self-micro-emulsified formulations on solid carriers is one of the best ways to create free-flowing powders for compression into tablet dosage form (SMET).

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About the book

Full name ATORVASTATIN SELF-EMULSIFIED TABLETS FORMULATION AND EVALUATION
Language English
Binding Book - Paperback
Date of issue 2022
Number of pages 76
EAN 9786205528082
ISBN 6205528088
Libristo code 42835871
Weight 131
Dimensions 150 x 220 x 5
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