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Advances in DNA Sequence-Specific Agents

Name: Advances in DNA Sequence-Specific Agents
Brand: Elsevier Science & Technology
SKU: 04809901
Price: 100.49 EUR
Availability: InStock
Author: J.B. Chaires
ISBN: 9781559381666

J.B. Chaires

Language

English

Book Hardback

Publishers Elsevier Science & Technology, July 1996

DNA sequence specificity is a sub-specialty in the general area of molecular recognition. This area... Full description

Libristo code: 04809901

246 b

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DNA sequence specificity is a sub-specialty in the general area of molecular recognition. This area includes macromolecular-molecular interactions (e.g., protein-DNA), oligomer-DNA interacitons (e.g., triple strands), and ligand-DNA interactions (e.g., drug-DNA). It is this latter group of DNA sequence specificity interactions that is the subject of Volumes 1 and 2 of Advances in DNA Sequence Specific Agents. As was the case for Volume 1, Part A also covers methodology, but in Volume 2 we include calorimetric titrations, molecular modeling, X-ray crystallographic and NMR structural studies, and transcriptional assays. Part B also follows the same format as Volume 1 and describes the sequence specificities and covalent and noncovalent interactions of small ligands with DNA. This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition.