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Actin Polymerization in Apicomplexan

Name: Actin Polymerization in Apicomplexan
Brand: Springer Nature Singapore
SKU: 33446841
Price: 107.29 EUR
Availability: InStock
Author: Avinash Kale
ISBN: 9789811374524

Avinash Kale

Language

English

Book Paperback

Libristo code: 33446841

Publishers Springer Nature Singapore, November 2020

This book discusses in detail the structural, evolutionary and functional role of actin and its regu... Full description

Libristo code: 33446841

263 b

107.29 € VAT included

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This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements.The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CP and CPbeta), cyclase-associated protein (CAP) and coronin 13-24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design.Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.